CORDIS Project
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This project investigates the role of NUDIX hydrolase 5 (NUDT5) in purine metabolism and its impact on tumor cell proliferation. By utilizing advanced techniques like proteomics and cryogenic electron microscopy, the research aims to uncover the molecular mechanisms behind NUDT5's functions, potentially leading to new…
Proliferation of tumour cells requires continuous DNA synthesis and energy supply.
Purine nucleotides are essential building blocks for DNA.
Recent research has highlighted the role of NUDIX hydrolase 5 (NUDT5) catalytic activity in nuclear ATP metabolism in breast cancer.
Notably, NUDT5 has also been suggested as a more general prognostic marker for various cancers, and NUDT5 depletion leads to suppression of tumour cell proliferation in a variety of model systems.
Strikingly, the host lab has…
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