CORDIS Project
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This project focuses on understanding G protein-coupled receptors (GPCRs) by analyzing their expression across human tissues. It aims to clarify how variations in GPCR expression affect drug responses and cell function.
G protein coupled receptors (GPCRs) are key regulators of cell homeostasis.
Given their importance in cell physiology, they have been extensively exploited as drug targets.
Despite this, many discordant observations on receptor signalling and on GPCR drug response remain unexplained.
Changes in receptor expression in different human tissues can be a key contributor to such differences in GPCR behaviour.
And still, no comprehensive study has characterized human GPCR transcriptomics and its impact…
UNITED KINGDOM RESEARCH AND INNOVATION
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