CORDIS Project
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This project investigates the role of a specific subset of dendritic cells, known as slanDC, in immune responses, particularly their maturation, survival, and interaction with other immune cells. The research aims to enhance understanding of slanDC's functions in autoimmunity, transplantation rejection, and cancer biol…
Dendritic cells (DC) are composed of multiple subsets with distinct functions at the interface of the innate and adaptive immunity.
Two major subsets of DC circulate in human peripheral blood: the myeloid DC (mDC) and the plasmacytoid DC (pDC), which can be distinguished by the expression of specific surface markers.
Within mDC, slanDC are the most abundant in human blood and are characterized by a selective phenotype (6-sulfo LacNAc+, CD1c–, CD11c+, CD14–, CD16+, CD45RA+, C5aR+).
They undergo s…
UNIVERSITA DEGLI STUDI DI VERONA
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