CORDIS Project
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This project investigates the connection between metabolism and gene expression by exploring how certain metabolic enzymes function as RNA-binding proteins. It aims to uncover the mRNA interactomes in eukaryotic cells, revealing how metabolic states influence RNA interactions and gene regulation.
The question of how (intermediary) metabolism and the regulation of gene expression are inter-connected represents one of the central challenges for the next decade of research.
This proposal aims to take a decisive stab at this question, exploiting hidden gems from the literature and modern day technologies.Some metabolic enzymes have been caught “moonlighting” as RNA-binding proteins and, intriguingly, their RNA-binding activities appear to be under the control of metabolites and/or cofactors…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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