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NextGen_IO focuses on immuno-oncology, aiming to enhance cancer treatment by targeting the hypoxia pathway in T cells. The project seeks to develop a small molecule inhibitor, discover therapeutic targets, and create hypoxia-inducible switches for T cell therapy.
NextGen_IO has a core focus on immuno-oncology, specifically on target discovery and drug development, to exploit several opportunities that the hypoxia pathway in T cells offers for the treatment of cancer.
It is well recognised that the clinical response of immunotherapies depends on the ability of T-cells to mount an effective effector response, persist in treated patients and avoid exhaustion and toxicities.
Several approaches to immunotherapy have shown promise in clinical trials, especiall…
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