CORDIS Project
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This project focuses on developing small molecules that target and degrade proteins at DNA damage sites, aiming to enhance cancer treatment by exploiting the vulnerabilities of cancer cells. The approach utilizes E3 ligases to selectively kill these cells, offering new methods to study DNA damage and potential therapeu…
Here I propose to use small molecules to degrade proteins specifically around sites of DNA damage by using the damage itself as a homing signal.
The approach will create new ways to study DNA damage, but will also offer translational possibilities in cancer.
Cancer cells are often acutely sensitive to DNA damage because they have one or more faulty DNA damage response (DDR) pathways – a feature that makes them highly dependent on their remaining DNA repair systems.
We will pioneer two novel and…
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