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The project EXPAND IT investigates the mechanisms of T-cell and B-cell expansion in the tumor microenvironment during cancer immunotherapy. By utilizing advanced single-cell technologies, it aims to identify the conditions that promote effective immune responses and enhance treatment efficacy for patients with advanced…
Cancer immunotherapy using immune checkpoint blockade (ICB) has revolutionized the treatment of advanced-stage cancers.
One of the major limitations of ICB is that durable responses are observed only in a subset of patients and in some specific cancer types.
We recently analyzed tumor biopsies from breast cancer patients collected during ICB and indeed observed only in a subset of patients that tumor-infiltrating T-cells undergo rapid expansion when exposed to ICB.
We characterized the gene expr…
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