CORDIS Project
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This project aims to develop innovative methods for drug discovery by utilizing a ring-distortion strategy to modify chemical structures. It combines advanced techniques in chemistry and engineering to create more efficient pathways for synthesizing new drug candidates, particularly focusing on heterocycles.
With ever-increasing costs for the development of new drugs, the call for the development of more cost-effective and efficient methodologies to streamline the access to new drug candidates is imperative.
To access new chemical space, the ring-distortion strategy – late-stage modification of rings to a variety of different functionalized cyclic and acyclic motifs – has proven a particularly successful approach.
Recently, numerous ring-expansion and functionalisation protocols to cyclopentanones,…
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
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