CORDIS Project
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The ExItALS project investigates the role of extracellular vesicles in the progression of amyotrophic lateral sclerosis, a neurodegenerative disease. It aims to analyze RNA contents in vesicles from astrocytes to understand their impact on motor neuron toxicity.
Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disorder that primarily targets upper and lower motor neurons.
The progression of the disease is mediated by altered intercellular communication in the spinal cord between neurons and glial cells.
Intercellular communication, mainly happening through extracellular vesicles (EVs) is responsible for the horizontal transfer of proteins and RNAs to recipient cells.
Recently, I proved that EVs released from ALS mutant astrocytes selectiv…
UNIVERSITA DEGLI STUDI DI TRENTO
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