CORDIS Project
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This project investigates the relationship between the structure of mammalian genomes and gene regulation, focusing on topologically associating domains (TADs). Using X-Chromosome Inactivation as a model, it aims to identify regulatory elements that influence gene expression and chromatin interactions.
Mammalian genomes are structurally organized into sub-chromosomal self-interacting domains called topologically associating domains (TADs).
Functionally, genes embedded within the same TAD appear to be co-regulated by their shared regulatory landscapes, suggesting the tendency of the genome to be divided into discrete regulatory domains.
Although disrupting TAD boundaries has been shown to result in aberrant patterns of gene expression, whether TAD organisation is cause or consequence of transcr…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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