CORDIS Project
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The EX-DR TB project aims to combat rising bedaquiline resistance in tuberculosis by enhancing diagnostic capabilities and evaluating new treatment regimens. It focuses on developing treatment recommendations and conducting a phase 3 clinical trial to support regulatory approval for innovative therapies.
In 2022, the World Health Organization (WHO) recommended bedaquiline (BDQ)-based, all-oral regimens including pretomanid (Pa), linezolid (L), and moxifloxacin (M) (BPaLM), lasting 6-9 months However, BDQ-resistance is rising dramatically and threatening these advancements.
Mozambique has reported BDQ resistance in 28% of MDR-TB isolates in 2024, up from 3% in 2016 and at 10% in South Africa (Ndjeka N, personal communication).
Spread of BDQ-R TB must be slowed by antibiotic stewardship through mo…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Germany, Munchen
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
South Africa, Rondebosch
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Spain, Tres Cantos
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
Italy, Milano
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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