CORDIS Project
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This research investigates the role of Wnt signaling in Alzheimer's Disease, focusing on the effects of DNA methylation on Wnt component expression. The goal is to understand how these changes impact synapse integrity and identify potential biomarkers for early diagnosis.
Growing evidence suggests that unbalanced Wnt signalling contributes to early stages of Alzheimer´s Disease (AD). mRNA levels of the Wnt antagonist Dikkoff1 (Dkk1) are increased in AD brains and by Amyloid-ß (Aß) in vitro.
Importantly, suppression of Dkk1 activity protects synapses from Aß.
Genome-Wide Association Studies also provide evidence for deficient Wnt signalling in AD.
The host laboratory has recently demonstrated that Dkk1 induced expression in the adult hippocampus leads to synapse l…
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