CORDIS Project
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This project investigates the use of extracellular vesicles to measure the expression of ATP-binding cassette transporters in blood and urine. By analyzing these vesicles, the project aims to predict drug pharmacokinetics and tailor therapeutic strategies without invasive biopsy procedures.
Drug transporters of the ATP-binding cassette (ABC) family (e.g., P-gp, MRP2 and BCRP) promote the intestinal, biliary and urinary excretion of a wide range of drugs and, thus, determine their bioavailability, therapeutic efficacy and toxicity.
Transporter expression is highly variable between individuals and within the same individual.
This may result in enormous differences in the plasma concentration of a drug, which for drugs with a narrow therapeutic index may result in life-threatening sit…
UNIVERSITATSKLINIKUM HEIDELBERG
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