CORDIS Project
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This project investigates the evolution of non-shivering thermogenesis in mammals and birds, focusing on the molecular innovations of the uncoupling protein 1. It aims to uncover the mechanisms of heat production and thermoregulation across different species using advanced molecular techniques and comparative approache…
Non-shivering thermogenesis (NST) is one of the most fascinating evolutionary achievements, enabling high body temperatures and successful radiation of mammals and birds into cold environments.
Yet, the evolutionary origin and molecular innovations enabling NST are unknown.
Using comparative approaches, my laboratory has recently transformed our view on mammalian NST by demonstrating that the thermogenic function of the mammalian heater protein, uncoupling protein 1 (UCP1), has only emerged late…
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