CORDIS Project
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This project investigates the human protein PrimPol, which plays a crucial role in DNA replication and damage tolerance. By employing a novel approach to study its structure and function, the research aims to enhance understanding of this enzyme and its potential as a target for cancer therapies.
The product of the human gene ccdc111, PrimPol, has been recently identified and characterized by the group of Professor Luis Blanco (CBMSO, Madrid, Spain).
This protein is capable of performing both priming and polymerase activities in human cells, contributing to DNA integrity and maintenance during its replication.
As an enzyme involved in tolerance to DNA damage, its malfunction gives rise to human diseases.
Thus, it might become a target for cancer therapy.
In order to exploit the benefits…
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