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EvoPlas investigates how non-transmissible plasmids are transferred between bacteria, contributing to the spread of antimicrobial resistance. By combining bioinformatics and experimental biology, the project aims to reveal the evolutionary origins and stability of these plasmids, ultimately enhancing our understanding…
Bacteria are extraordinarily adaptive organisms spread all over the globe and making up about half of the cells in our bodies.
Their main source of novel functions is horizontal gene transfer, usually prompted by mobile genetic elements such as plasmids, that provide them with a wide range of traits.
Plasmid conjugation is the main mechanism of dissemination of antimicrobial resistance (AMR), an increasingly important health problem.
However, more than half of the plasmids found in bacterial gen…
INSTITUT PASTEUR
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