CORDIS Project
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This project investigates the dynamics of RNA splicing to understand how different regions of genes are regulated during evolution. By utilizing advanced RNA sequencing techniques and machine learning, it aims to identify how splicing pressures influence genetic variation and disease-related mutations.
The need to preserve correct splicing is a major source of constraint on sequence evolution.
This includes selection on the splice sites as well as on regulatory elements in exons and introns.
Are all exons and introns constrained similarly by splicing related pressures?
This is a crucial problem not only for understanding genome evolution but also for predicting where disease-causing mutations occur.Any variation in the prevalence of splicing information most likely reflects mechanistic variati…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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