CORDIS Project
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This project investigates the genetic mechanisms driving phenotypic diversity in mammals by studying transcription factor binding in mouse species. It aims to understand how genetic variations affect gene regulation and expression, using advanced experimental techniques to explore evolutionary processes.
The genetic differences found in gene regulatory regions are the largest contributing factor to the diversity of phenotypes within and between mammalian species.
However, the micro-evolutionary mechanisms active in closely-related species remain poorly explored, particularly in mammals.In Aim 1, we will exploit five recently sequenced mouse species to determine how often genetic sequence differences alter both the genome-wide binding and regulatory output of a core set of tissue-specific transcr…
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