CORDIS Project
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This project explores the evolution of multidrug-resistant Mycobacterium tuberculosis, focusing on the genetic mutations that confer drug resistance. It combines laboratory experiments with epidemiological data to understand the emergence and transmission of resistant strains.
Multidrug-resistant bacteria are a global threat to public health and the economy.
Studies in model organisms suggest compensatory evolution and epistatic interactions between drug resistance-conferring mutations are important drivers of drug resistance.
However, the relevance of these factors for the emergence and transmission of human pathogenic bacteria has not been established.
To bridge the gap between laboratory experimentation and epidemiology, I propose a multidisciplinary approach focus…
SWISS TPH SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE
SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
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