CORDIS Project
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This project investigates how biochemical networks in yeast evolve without losing fitness, focusing on symmetry-breaking processes. By studying adaptive mutations and creating minimal evolvable networks, it aims to understand the relationship between network structure, fitness, and evolvability.
How do organisms evolve? I propose to study how biochemical networks reorganize during evolution without compromising fitness.
This is a complex problem: firstly, it is hard to know if a mutation increased fitness because this depends on the environment it arose in, which is typically unknown.
Secondly, it is hard to find out how adaptive mutations improve fitness, because in cells, all biochemical networks are connected. I will reduce the complexity by two approaches, focused on symmetry-breaki…
TECHNISCHE UNIVERSITEIT DELFT
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