CORDIS Project
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This project investigates how protein complexes evolve, focusing on the roles of natural selection and neutral processes in their development. By using ancestral sequence reconstruction and quantitative biochemistry, it aims to understand the evolutionary dynamics of protein interactions in various model systems.
Almost all proteins perform their functions as part of protein complexes.
These assemblies are intricate and often beautiful examples of evolution?s capacity to generate complexity.
But are they built by natural selection?
My recent work has revealed that they may in fact be produced and maintained across vast time scales by neutral processes, even if they provide no adaptive benefit at all.
In this proposal, I will test this radical idea by bringing together ancestral sequence reconstruction an…
PHILIPPS UNIVERSITAET MARBURG
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