CORDIS Project
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This project investigates how extracellular vesicles from melanoma cells influence the effectiveness of immune checkpoint inhibitors in treating metastatic melanoma. By understanding the role of these vesicles in immune signaling, the research aims to enhance treatment outcomes for patients resistant to current therapi…
Melanoma is the deadliest of the skin cancers.
Immune checkpoint inhibitors (ICI), which are blocking antibodies that help to restore antitumor immunity, are currently used for the treatment of metastatic melanoma.
However, only approximately 20% of the patients respond to ICI.
Understanding the molecular mechanisms behind the resistance to these therapies is essential to predict patients' response and increase treatment success.
Extracellular vesicles(EVs), nanosized structures released by virt…
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
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