CORDIS Project
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This project investigates the assembly and maturation of eukaryotic ribosomes in budding yeast, focusing on the role of non-ribosomal factors during pre-ribosome assembly and export. It aims to develop new biochemical tools and high-throughput screening methods to map these processes and enhance understanding of riboso…
In all living cells, the important task of protein synthesis is carried out by the ribosome. A substantial amount of cellular energy and resources is utilized to manufacture ribosomal subunits.
In contrast to prokaryotes, eukaryotic ribosome assembly requires a multitude of conserved non-ribosomal trans-acting factors, which transiently associate with pre-ribosomal particles at distinct assembly stages and perform specific maturation steps.Large-scale proteomic approaches in budding yeast, have…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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