CORDIS Project
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This project investigates the mechanisms of DNA replication in eukaryotic cells, focusing on the regulation of replication origins. By studying the licensing and initiation processes, it aims to understand how defects in these mechanisms contribute to genome instability, particularly in cancer.
In each cell cycle, eukaryotic cells must faithfully replicate large genomes in a relatively short time.
This is accomplished by initiating DNA replication from many replication origins distributed along chromosomes.
Ensuring that each origin is efficiently activated once and only once per cell cycle is crucial for maintaining the integrity of the genome.
Recent evidence indicates that defects in the regulation of origin firing may be important contributors to genome instability in cancer.
Stric…
THE FRANCIS CRICK INSTITUTE LIMITED
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