CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of the SirT1 enzyme in regulating gene expression related to aggrecan and collagen in articular cartilage, aiming to uncover mechanisms that could lead to new treatments for osteoarthritis. The research focuses on the interactions between SirT1 and transcription factors Sp1 and Sox9 t…
Osteoarthritis (OA) is a degenerative joint disease of the articular cartilage (AC) characterized by accelerated extracellular matrix (ECM) degradation and severe pain- dysfunction.The chromatin modifying enzyme, SirT1 has been shown to affect cartilage-type ECM gene expression.
More specifically, SirT1 forms complexes with Sp1/Sox9 transcription factors (TFs), and induces collagen IIa1 (Coll-II) transcription.
Similar to Coll-II, aggrecan has also been established to positively correlate with S…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
