CORDIS Project
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This project investigates the role of estrogens in granulosa cell tumors, a rare ovarian cancer. It aims to understand how estrogens may promote tumor growth and metastasis through specific molecular pathways, particularly the phosphatidyl-inositol 3 kinase pathway, using both in vitro and in vivo models.
Granulosa cell tumours (GCT) are a rare form of malignancy affecting women of all ages.
Because GCT display a high propensity to recurrence and there is no efficient curative treatment beyond surgery, ~ 20% of adult patients die of the consequences of their tumour.
However, despite the importance and insidiousness of GCT, very little is known of its molecular etiology.
Although most GCT produce estrogens and strongly express estrogen receptor ß (ERß), the role of estrogens in GCT pathogenesis is…
Université Paris Diderot-Paris 7
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