CORDIS Project
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This project investigates DNA damage and its repair mechanisms, focusing on nucleotide excision repair, which is vital for preventing mutations and cancer. It aims to understand how different repair pathways function and their implications for aging and disease.
DNA damage is a fact of life.
Lesions hamper genome function, induce mutations causing cancer and trigger senescence or cell death contributing to aging.
Therefore cells are equipped with a sophisticated defence machinery:
DNA Damage Response (DDR) including different repair pathways.
Nucleotide excision repair (NER) is versatile repair process, eliminating helix-distorting lesions, e.g. bulky adducts and sun-induced lesions.
Very cytotoxic transcription-blocking lesions are removed by a dedicat…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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