CORDIS Project
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This project investigates the mechanisms of protein removal from the endoplasmic reticulum, focusing on the retro-translocation process known as ER-associated protein degradation (ERAD). It also explores the protein import system in the apicoplast of malaria parasites, aiming to understand the unique machinery involved…
The removal of misfolded proteins is an essential process in all cells.
Failure to dispose of such proteins often results in disease. A particularly intriguing process serves to discard misfolded proteins from the endoplasmic reticulum (ER).
The ER does not itself degrade proteins, so machinery has evolved that moves misfolded proteins into the cytosol where they can be degraded by the proteasome.
This retro-translocation process is called ERAD (for ER-associated protein degradation).
By compari…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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