CORDIS Project
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This project explores chromatin regulators as new biomarkers to predict breast cancer responses to the drug docetaxel. It aims to establish a genetic signature that can help identify patients who will benefit from treatment, potentially improving clinical outcomes.
The aim of this proposal is to showcase that chromatin regulators represent a novel class of biomarkers that can predict the response to individual drugs.
The proof of concept will be established by validating our recent discovery of a 28-gene signature of chromatin regulators that predicts the response of 26 out of 31 patient-derived xenograft breast cancer models to docetaxel.
Notably, in patients treated with docetaxel, though all are subjected to toxic side effects, less than half of them cl…
INSTITUT CURIE
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