CORDIS Project
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This study explores the role of epigenetic factors in heritable diseases by analyzing monozygotic twins with discordant traits. It aims to identify epigenetic signals linked to various age-related diseases using advanced genetic techniques.
Twin studies traditionally have been used to assess the relative contributions of genetic and environmental factors.
Nearly all common diseases and traits have now been found to be heritable and GWA studies are discovering many novel genes.
However 95% of the heritability is not yet identified and discordances within identical (MZ) twin pairs cannot be explained by known environmental factors.
The missing heritability could be due to epigenetic factors- which are ideally studied with twins.
The…
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