CORDIS Project
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The project aims to create selective chemical probes for studying histone modifications that regulate gene expression. By developing a novel discovery platform, it seeks to enhance understanding of epigenetic regulation and provide tools for potential therapeutic applications.
Posttranslational modifications on histones play crucial roles in the epigenetic regulation of eukaryotic gene expression.
Chemical modifications that occur on histone tails include acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation.
This chemical diversity together with the positions and combinations of these modifications give rise to complex networks of highly controlled gene expression programs.
The identification and characterisation of chromatin-associated proteins…
UNIVERSITY OF NEWCASTLE UPON TYNE
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United Kingdom, Oxford
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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