CORDIS Project
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This project investigates how epithelial cells respond to tissue injury, focusing on their ability to revert to a stem cell-like state and contribute to tissue regeneration. Using the oesophagus as a model, it aims to uncover the molecular mechanisms and interactions that influence cell behavior and their implications…
Epithelial tissues have evolutionarily adapted to rapidly react to tissue disruption in order to restore the epithelial barrier and ensure survival.
The dynamic behaviour of epithelial cells in response to injury represents a decisive mechanism to recover tissue integrity.
Following injury, not only cycling but also differentiating epithelial cells are able to revert back, reacquiring stem cell-like behaviour and contributing to tissue regeneration.
Although this cellular plasticity is normally…
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