CORDIS Project
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This project investigates how intra-epithelial lymphocytes interact with the intestinal microbiota to balance immune tolerance and responses. By using advanced sequencing techniques, it aims to understand the impact of microbial composition on immune functions and the intestinal barrier, potentially influencing autoimm…
This proposal aims to study the interactions between specialised cells of the immune system, the intra-epithelial cells (IELs) which are ideally positioned in close proximity of the epithelial cells, and the intestinal microbiota.It aims to provide insights into how IELs are able to maintain tolerance to beneficial bacteria while enhancing immune responses against undesirable ones.
This will be achieved using deep-sequencing techniques of both the intestinal tissues, IEL effector subsets and the…
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