CORDIS Project
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This project explores the mechanisms behind Polycomb-mediated gene regulation in plants, focusing on the Arabidopsis FLC gene. It aims to uncover how epigenetic switches operate at a molecular level, contributing to our understanding of gene expression and developmental processes.
Polycomb-mediated epigenetic regulation of gene expression is central to development and environmental plasticity in most eukaryotes.
Polycomb Repressive Complex 2 (PRC2) is targeted to genomic sites, known as nucleation regions or Polycomb Response elements, and switches those targets to an epigenetically silenced state.
But what constitutes the switching mechanism is unknown.
Core epigenetic switching mechanisms have proven difficult to elucidate due to the complex molecular feedbacks involved…
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