CORDIS Project
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This project investigates how modifications to ribosomal RNA (rRNA) can regulate ribosome function and adaptability in response to environmental changes. By profiling various rRNA modifications across different life forms and growth conditions, the research aims to uncover the regulatory mechanisms and evolutionary sig…
A remarkable diversity of post-transcriptional modifications adorn the ribosomal RNA (rRNA) throughout all domains of life.
While initially conceptualized as a constitutive component of the ribosome, recent evidence demonstrates that some modifications are only present on a fraction of cellular ribosomes, and our lab recently revealed unprecedented environmentally-mediated dynamics of an rRNA modification.
This suggests that some rRNA modification may serve as a tunable layer for regulation of r…
WEIZMANN INSTITUTE OF SCIENCE
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