CORDIS Project
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This research focuses on the mechanisms of nucleosome assembly during DNA replication, which is essential for maintaining epigenetic information. By studying the role of specific proteins in this process, the project aims to reveal how cells ensure proper inheritance of genetic material.
Proper inheritance of the epigenetic information during cell division controls cell fate decisions, tissues homeostasis and development, ensuring disease avoidance.
We have little understanding however of the mechanisms by which epigenetic information, specifically histone post-translational modifications in nucleosomes, are replicated in parallel to the DNA prior to cell division.
This process strictly depends on proper nucleosome formation on the newly synthesized DNA strands.
Here, I will stu…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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