CORDIS Project
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This project investigates the role of TET proteins in DNA methylation during mammalian development and cellular reprogramming. It aims to understand how these proteins influence stem cell differentiation and pluripotency, with potential applications in disease modeling and regenerative medicine.
DNA methylation is critical during mammalian development, generally represses transcription when present at gene promoters and regulates cell lineage-specific gene expression programs.
Conversely, during cellular reprogramming, efficient erasure of DNA methylation is essential for reactivation of previously silenced genes and for attaining pluripotency.
The identity of such “DNA demethylase(s)” has been elusive until our recent discovery of the Tet family of dioxygenases.
As a research fellow in…
KATHOLIEKE UNIVERSITEIT LEUVEN
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