CORDIS Project
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This project focuses on developing a model for Diabetic Nephropathy using human embryonic stem cell-derived kidney organoids. It aims to replicate the disease's characteristics to better understand its progression and identify potential therapeutic targets.
Diabetic Nephropathy is the leading cause of end-stage renal disease (ESRD).
To date, treatment of DN is mainly based on drugs acting on glycaemic and blood pressure control, as there is no validated therapy able to stop the progression towards renal failure.
One of the main impediments for developing new therapies for DN has been the lack of a good preclinical model which can recapitulate important functional, structural, and molecular features of advanced human diabetic kidney disease.
Here, w…
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
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