CORDIS Project
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This project investigates the differentiation of oligodendrocyte precursor cells and their role in myelination, particularly in multiple sclerosis. It focuses on the epigenetic mechanisms that influence their development and potential.
Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process which is defective in multiple sclerosis (MS).
Although OL precursors can initially promote remyelination in MS, this process eventually fails. OL precursors (OPCs) go through several epigenetic states during development and MS, which ultimately define their potential to differentiate and myelinate.
Transcription factors such as Sox2, Sox10 and Sox9 are key regulators of OL development.
However, it is unclear wh…
KAROLINSKA INSTITUTET
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