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The EPINuc project develops a novel assay to analyze cell-free DNA from blood samples for cancer diagnostics. By profiling the epigenetic modifications of nucleosomes, it aims to detect colorectal cancer early through a non-invasive blood test, providing a cost-effective alternative to traditional screening methods.
The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in medicine, with developing methods aiming to utilize it for diagnostics of cancer and additional pathologies.
Most liquid biopsy methods are sequencing-based and provide limited information, usually relying on the detection of rare cancer-associated mutations.
Therefore, they are costly and highly limited in their sensitivity.
Importantly, blood cfDNA consists predominantly in the form of nucleosomes, which ma…
WEIZMANN INSTITUTE OF SCIENCE
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