CORDIS Project
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This project investigates how chromatin accessibility and DNA methylation influence cell fate decisions during mouse development. Using advanced sequencing techniques, it aims to reveal the connection between these factors and gene regulation at the single-cell level, enhancing our understanding of stem cell research.
A fundamental question in biology is how different cell fates are generated.
While it is clear that extensive remodelling of chromatin accessibility and DNA methylation is an essential step in early mammalian development, their roles in cell fate specification remain unclear.
Furthermore, it is not known to what extent cell-to-cell differences in gene expression regulation affect cell fate decisions.
The aim of this proposal is to uncover the roles of chromatin accessibility and DNAme in gene re…
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