CORDIS Project
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This project investigates how acute myeloid leukemia interacts with its bone marrow niche, focusing on the role of leukemic stem cells and their effect on the surrounding environment. By utilizing advanced sequencing and computational models, the research aims to uncover mechanisms that could lead to new therapeutic st…
The bone marrow is one of the most dynamic adult stem cell niches containing hematopoietic stem cells and non-hematopoietic mesenchymal stem and stromal cells, which make up the bone marrow niche.
The niche regulates the immune system and constitutes a major determinant of chemoresistance in hematological malignancies, including acute myeloid leukemia (AML).
Identifying the mechanisms by which AML interacts with its niche will open novel therapeutic avenues.AML is driven and maintained by leukem…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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