CORDIS Project
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This research focuses on the mechanisms of DNA replication and epigenetic memory, particularly how histone modifications are maintained during cell division. By using advanced techniques, the project aims to uncover the principles of chromatin restoration and its impact on gene expression and cell identity.
DNA replication not only involves the copying of the genome to propagate cell identity to daughter cells but also of the epigenome, where histones and their post-translational modifications (PTM) are accurately maintained in replicated chromatin.
This is achieved by a strikingly coordinated process that ensures accurate, symmetric recycling of H3-H4 tetramers to both daughter strands, thus forming the basis of epigenetic memory.
Recently, I identified H2A-H2B PTMs to be also symmetrically recycl…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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