CORDIS Project
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This project investigates how non-mutational epigenetic changes influence the metastatic transition in colon cancer. Using patient-derived organoids, it aims to profile chromatin modifications and identify transcription factors that regulate pro-metastatic gene networks, enhancing our understanding of cancer evolution.
Cancer development is a convoluted biological process that reshapes cellular identity.
Genetic mutations are crucial in driving such process, yet fail to fully explain metastatic transition—a critical step in cancer evolution.
For this reason, reprogramming driven by non-mutational epigenetic changes is increasingly recognized as a potential mechanism by which cancer cells acquire metastatic properties.
Despite the genetic heterogeneity, specific transcriptional programs are activated to promote…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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