CORDIS Project
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This project investigates how dynamic changes in the mechanical properties of the extracellular matrix influence the development and organization of the intestine epithelium. By using light-responsive hydrogels, it aims to understand how these properties affect stem cell behavior and tissue patterning during intestinal…
Intestine epithelium (IE) compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix (ECM), especially viscoelasticity.
Recent studies have revealed substrate mechanical properties have clear influences on intestine stem cell (ISC) fate, IE polarity, self-organization and morphogenesis.
However, most of these investigations were performed in constant and static conditions, neglecting the active and dyn…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, PARIS
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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