CORDIS Project
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This project investigates the role of Arid1A in liver progenitor cells to understand liver cancer mechanisms. By utilizing 3D organoid cultures and genome-wide analyses, it aims to reveal insights into tumor suppression and liver regeneration.
Liver cancer is the fifth most common malignancy in men and the eighth in women worldwide.
Of note, liver cancer is tightly associated with tissue damage due to the high metabolic and drug detoxification activity of the liver.
Increasing evidence demonstrates that toxic agents induce the activation of a resident ductal-progenitor population capable of regenerating the tissue.
Therefore, understanding molecular mechanisms governing liver progenitor cells is essential for preventing tumour initiat…
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