CORDIS Project
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This project focuses on understanding how epigenetic mechanisms contribute to phenotypic variation by developing techniques to profile the epigenome at the single-cell level. It aims to create methods for mapping histone modifications and chromatin organization, linking these to gene expression.
Phenotypic variation arises from the heritable acquisition of cell-type specific gene-expression programs.
Key in understanding cellular specification is to elucidate the epigenetic mechanism that underlies transcriptional heterogeneity.
Thus a central question in biology is how cell-to-cell variability in the epigenome contributes to the emergence of phenotypic differences.
However, current techniques to profile the epigenome require populations of cells and consequently present ensemble avera…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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