CORDIS Project
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This project investigates how different signals during development create epigenetic diversity in hematopoietic stem cells. By using advanced techniques, it aims to map the epigenetic states that influence stem cell behavior and inheritance.
During the development of multicellular organisms, cells from the same niche can be stochastically exposed to different signals and stimuli, and this variability has the potential to create epigenetic heterogeneity across cell populations.
Importantly, this heterogeneity can confer individual cells different functional properties or different capacities to respond to the same stimuli.
During the last decade, multiple laboratories have reported the existence of hematopoietic stem cell (HSC) clone…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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