CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project aims to model a neurodevelopmental disorder linked to glycosylation by creating organoids that mimic the condition. It will explore the underlying mechanisms of the disorder to identify potential therapeutic approaches.
An increasing number of neurodevelopmental pathologies are associated with disorders of glycosylation.
One such disorder is MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy), which is primarily caused by brain somatic mutations in the gene SLC35A2.
This gene encodes the sole known ER/Golgi UDP-galactose transporter, and mutations in SLC35A2 result in loss of galactose from glycans.
The only therapeutic approach to control MOGHE-related seizures is s…
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
