CORDIS Project
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This project investigates the role of epigenetic changes in the differentiation of stem cells into specialized cell types. By analyzing DNA methylation and histone modifications, it aims to understand how these changes influence gene expression and cellular identity.
Differentiation events in mammalian development involve stable resetting of transcriptional programs, which entails changes in the epigenetic state of target sequences defined by modifications of DNA and bound nucleosomes.
These recently identified epigenetic layers modulate DNA accessibility in a positive and negative manner and thus could make genetic readouts context-dependent and dynamic.
The proposed project aims to quantify the epigenetic contribution to cellular differentiation as a key e…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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